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Neves,C.D.C.; Lacerda,A.C.R.; Lima,L.P.; Lage,V.K.S.; Balthazar,C.H.; Leite,H.R.; Mendonça,V.A.. |
Studies suggest that brain-derived neurotrophic factor (BDNF) and the hypothalamic-pituitary-adrenal (HPA) axis modulate dopaminergic activity in response to nicotine and that the concentrations of BDNF and cortisol seem to be dependent on the amount and duration of smoking. Therefore, we investigated BDNF and cortisol levels in smokers ranked by daily cigarette consumption. Twenty-seven adult males (13 non-smokers and 14 smokers) participated in the study. The smokers were divided in two groups: light (n=7) and heavy smokers (n=7). Anthropometric parameters and age were paired between the groups, and plasma BDNF and salivary cortisol levels were measured. Saliva samples were collected on awakening, 30 min after awakening, at 10:00 and 12:00 am, 5:00 and... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: BDNF; Nicotine consumption; HPA axis; Addiction; Reward system. |
Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001200608 |
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Chen Cárdenas,S. M; Mayer,N; Romanini,M. C; Rolando,A. N; Liaudat,A. C; Brun,N; Vivas,A; Gauna,H. F; Rodríguez,N. |
Stress in pregnant rats alters the pattern of secretion of corticosterone (COR) and modifies transplacentally hypothalamic-pituitary-adrenal axis (HPA) fetus. Prenatal stress during the critical hypothalamic differentiation is related to decreased fertility of male offspring by an increase in the basal level of COR. This modification could induce long-term changes in the process of apoptosis in the testis. However, early postnatal handling increases maternal behavior and could reverse the effects caused by increased secretion of COR. The aim of this research was to investigate the effects of early postnatal stimulation of male rats prenatal stressed by chronic immobilization during the last two weeks of pregnancy, on the hypothalamic-pituitary-gonadal axis... |
Tipo: Journal article |
Palavras-chave: Early postnatal stimulation; Prenatal stress; HPA axis; HPG axis; Rats; Apoptosis. |
Ano: 2013 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200065 |
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